Preferred conformations of a linear RGD tripeptide
نویسندگان
چکیده
منابع مشابه
Tripeptide arginyl-glycyl-aspartic acid (RGD) for delivery of Cyclophosphamide anticancer drug: A computational approach
Density functional theory (DFT) calculations were performed on tripeptide arginyl-glycyl-aspartic acid (RGD) as an efficient drug carrier to deliver the commercially famous cyclophosphamide (CP) anticancer drug within ethanol solution. The most negative binding energy (-5.22 kcal/mol) was measured for the CP-RGD-7 created through the H-bond interaction between the P=O (phosphoryl) oxygen atom o...
متن کاملTripeptide RGD-dependent adhesion of articular chondrocytes to synovial fibroblasts.
Cell-cell interactions play an important role in the development of cartilage. Heterologous and homologous cell-cell interactions are critical for chondrogenic differentiation during development. Cell-cell interactions in the formation of fracture callus and cartilage neoplasia also invoke the process of cartilage differentiation. We have investigated cell-cell interactions between articular ch...
متن کاملConformations of Linear DNA
We examine the conformations of a model for underand overwound DNA. The molecule is represented as a cylindrically symmetric elastic string subjected to a stretching force and to constraints corresponding to a specification of the link number. We derive a fundamental relation between the Euler angles that describe the curve and the topological linking number. Analytical expressions for the spat...
متن کاملThe inhibitory effects of integrin antibodies and the RGD tripeptide on early eye development.
PURPOSE The authors investigated the effects of probes that disrupt integrin-extracellular matrix interactions on early eye development. METHODS Antibodies and peptides that have been shown in other studies to block the interaction of cell surface integrins with various ligands were microinjected into the preoptic regions of chick embryos. Eye morphogenesis and biochemical differentiation of ...
متن کاملThe preferred all-gauche conformations in 3-fluoro-1,2-propanediol.
A competition between the terminal fluorine and hydroxyl groups by the central hydroxyl group as hydrogen bond donor in 3-fluoro-1,2-propanediol would be expected to dictate the conformational isomerism of this compound, but also the repulsion between the electronegative and bulky vicinal substituents. Indeed, an intramolecular hydrogen bond has been verified only for a local minimum using QTAI...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Peptide Research
سال: 2001
ISSN: 1397-002X
DOI: 10.1034/j.1399-3011.2001.058001090.x